{"id":1830,"date":"2023-04-13T17:43:13","date_gmt":"2023-04-13T15:43:13","guid":{"rendered":"https:\/\/demoucelle.sites-stag.agency\/uncategorized\/the-demoucelle-parkinson-charity-supports-research-to-find-a-molecule-that-can-clean-up-the-brain\/"},"modified":"2026-08-23T01:37:24","modified_gmt":"2026-08-22T23:37:24","slug":"the-demoucelle-parkinson-charity-supports-research-to-find-a-molecule-that-can-clean-up-the-brain","status":"publish","type":"post","link":"https:\/\/demoucelle.sites-stag.agency\/fr\/research\/dpc-supported-research\/the-demoucelle-parkinson-charity-supports-research-to-find-a-molecule-that-can-clean-up-the-brain\/","title":{"rendered":"Le Demoucelle Parkinson Charity soutient la recherche visant \u00e0 d\u00e9couvrir une mol\u00e9cule capable de \u2018 nettoyer \u2019 le cerveau"},"content":{"rendered":"

<\/a><\/p>\n\n\n\n

Cet article a \u00e9t\u00e9 traduit \u00e0 l'aide de Deepl. Nous vous prions de bien vouloir nous excuser pour les \u00e9ventuelles erreurs ou formulations \u00e9tranges.<\/mark><\/pre>\n\n\n\n
The Demoucelle Parkinson Charity has decided to support a research project that aims to improve the ability of brain cells to deal with \u2018trash\u2019 i.e. old and damaged molecules. It is hoped that by reducing the amount of waste buildup in the brain, it will be possible to slow the progression of Parkinson\u2019s disease.<\/p>\n\n\n\n
Le Demoucelle Parkinson Charity collabore avec la Fondation Michael J. Fox pour la recherche sur la maladie de Parkinson afin de soutenir cette \u00e9tude.<\/p>\n\n\n\n
Pour plus d'informations sur cette \u00e9tude, veuillez cliquer sur ce lien ou lire le texte ci-dessous.<\/p>\n\n\n\n
https:\/\/www.michaeljfox.org\/grant\/testing-small-molecules-activate-removal-cellular-debris-treatment-parkinsons-disease<\/a><\/p>\n\n\n\n
\u2014\u2014\u2014\u2014\u2014<\/strong><\/p>\n\n\n\n
Testing Small M<\/strong>olecules that Activate Removal of Cellular Debris for the Treatment of Parkinson\u2019s Disease<\/strong><\/p>\n\n\n\n
Justification de l'\u00e9tude :<\/strong><\/em>
People with Parkinson\u2019s disease (PD) exhibit a diminished ability to remove cellular trash \u2014 including old and damaged molecules and organelles \u2014 from the brain. This impairment is caused by a reduction in trash collection and delivery (a process called macroautophagy) and a decline in the number and effectiveness of trash cans (compartments called lysosomes). Activation of TRPML1, a channel that resides on the lysosome, has been shown to enhance macroautophagy and to increase lysosome function and number in cells. Therapeutics that boost TRPML1 activity could therefore alleviate the symptoms and progression of PD.<\/em><\/p>\n\n\n\n
Hypoth\u00e8se :<\/strong>\u00a0<\/em>
We hypothesize that developing small compounds that can activate TRPML1 should also enhance macroautophagy and increase lysosome function in animals and potentially in humans.<\/em><\/p>\n\n\n\n
Conception de l'\u00e9tude :\u00a0<\/strong><\/em>
In this project, we seek to demonstrate that activation of TRPML1 increases macroautophagy and lysosome growth signaling in animals, and that this activation and its subsequent effects are dose dependent. We will then determine whether and how much activation of TRPML1 is needed to show beneficial effects in animal models of PD. Lastly, we seek to lay the foundation for development of an assay or suite of assays that will allow us to measure activation of TRPML1 and its subsequent activation of macroautophagy and lysosome growth signaling in future clinical trials.<\/em><\/p>\n\n\n\n
Impact on Diagnosis\/Treatment of Parkinson\u2019s Disease:<\/strong><\/em>
Establishing that activation of TRPML1 increases macroautophagy and lysosome growth signaling in animals, and that these effects can be monitored in potential future clinical trials, would provide a strong body of evidence supporting the development of small compounds that can activate TRPML1 for the treatment of PD.<\/em><\/p>\n\n\n\n
Prochaines \u00e9tapes de d\u00e9veloppement :<\/strong><\/em>
Success in this grant would provide strong support for the continued advancement of Libra\u2019s small compound TRPML1 activators into animal toxicology studies, which are required for advancement into clinical safety evaluation in people with PD and healthy volunteers.<\/em><\/p>\n\n\n\n
Photo de Michael Longmire sur Unsplash<\/p>","protected":false},"excerpt":{"rendered":"
En savoir plus sur le 14e projet soutenu par le DPC<\/p>","protected":false},"author":1,"featured_media":3671,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-1830","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-dpc-supported-research"],"_links":{"self":[{"href":"https:\/\/demoucelle.sites-stag.agency\/fr\/wp-json\/wp\/v2\/posts\/1830","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/demoucelle.sites-stag.agency\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/demoucelle.sites-stag.agency\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/demoucelle.sites-stag.agency\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/demoucelle.sites-stag.agency\/fr\/wp-json\/wp\/v2\/comments?post=1830"}],"version-history":[{"count":3,"href":"https:\/\/demoucelle.sites-stag.agency\/fr\/wp-json\/wp\/v2\/posts\/1830\/revisions"}],"predecessor-version":[{"id":4117,"href":"https:\/\/demoucelle.sites-stag.agency\/fr\/wp-json\/wp\/v2\/posts\/1830\/revisions\/4117"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/demoucelle.sites-stag.agency\/fr\/wp-json\/wp\/v2\/media\/3671"}],"wp:attachment":[{"href":"https:\/\/demoucelle.sites-stag.agency\/fr\/wp-json\/wp\/v2\/media?parent=1830"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/demoucelle.sites-stag.agency\/fr\/wp-json\/wp\/v2\/categories?post=1830"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/demoucelle.sites-stag.agency\/fr\/wp-json\/wp\/v2\/tags?post=1830"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}