{"id":1662,"date":"2021-10-15T00:00:09","date_gmt":"2021-10-14T22:00:09","guid":{"rendered":"https:\/\/demoucelle.sites-stag.agency\/uncategorized\/the-demoucelle-parkinson-charity-invests-in-stem-cell-therapy-research-project\/"},"modified":"2026-08-23T02:18:31","modified_gmt":"2026-08-23T00:18:31","slug":"the-demoucelle-parkinson-charity-invests-in-stem-cell-therapy-research-project","status":"publish","type":"post","link":"https:\/\/demoucelle.sites-stag.agency\/fr\/research\/dpc-supported-research\/the-demoucelle-parkinson-charity-invests-in-stem-cell-therapy-research-project\/","title":{"rendered":"Le Demoucelle Parkinson Charity investit dans un projet de recherche sur la th\u00e9rapie par cellules souches"},"content":{"rendered":"
Cet article a \u00e9t\u00e9 traduit \u00e0 l'aide de Deepl. Nous vous prions de bien vouloir nous excuser pour les \u00e9ventuelles erreurs ou formulations \u00e9tranges.<\/mark><\/pre>\n\n\n\n
The Demoucelle Parkinson Charity has decided to support human trials of a stem cell therapy that it is hoped can significantly slow, or even, stop Parkinson\u2019s disease. The charity\u2019s investment committee met in September and decided to provide a grant to this US-based research project, which is also supported by The Michael J. Fox Foundation for Parkinson\u2019s Research.<\/p>\n\n\n\n
Pour plus d'informations sur cette \u00e9tude, veuillez cliquer sur ce lien ou lire le texte ci-dessous.<\/p>\n\n\n\n
https:\/\/www.michaeljfox.org\/grant\/phase-ii-trial-bone-marrow-derived-mesenchymal-stem-cells-disease-modifying-therapy<\/a><\/p>\n\n\n\n
 ————————————-<\/strong><\/p>\n\n\n\n
Phase II Trial of Bone Marrow-Derived Mesenchymal Stem Cells as a Disease-Modifying Therapy for Parkinson\u2019s Disease.<\/strong><\/em><\/p>\n\n\n\n
Justification de l'\u00e9tude : <\/strong><\/em>
Chronic brain inflammation plays a critical role in the development and progression of Parkinson\u2019s disease. This inflammation damages the brain, disrupts the blood-brain barrier, and creates a pro-inflammatory condition. Mesenchymal stem cells can modulate immune response and are capable of migrating to sites of injury. Such stem cells are able to recognize and react to the environment by secreting several molecules, including anti-inflammatory molecules and growth factors that interact with the surrounding cells, that can allow damaged brain cells to regenerate.<\/em><\/p>\n\n\n\n
Hypoth\u00e8se :<\/strong><\/em>
Our hypothesis is that multiple intravenous infusions of mesenchymal stem cells from the bone marrow of a healthy donor will significantly slow the progression of Parkinson\u2019s disease when compared to placebo over a year.<\/em><\/p>\n\n\n\n
Conception de l'\u00e9tude :<\/strong><\/em>
We aim to recruit 45 patients with early to moderate Parkinson\u2019s disease and assign them to one of three treatment arms. Group one will receive 3 infusions of placebo every 3 months; group two will receive 2 infusions of 10 X 106<\/sup> MSC\/Kg every 3 months and 1 placebo infusion; and group three will receive 3 infusions of 10 X 106<\/sup> MSC\/Kg every 3 months. All subjects will receive 3 infusions, with 3 months intervals in between. They will be monitored for adverse reactions and clinical improvement for a year after the last infusion.<\/em><\/p>\n\n\n\n
Impact on Diagnosis\/Treatment of Parkinson\u2019s Disease:<\/strong><\/em>
Cell-based therapy has the potential to be a transformative approach in the treatment of Parkinson\u2019s disease. By ending the destructive inflammatory process, mesenchymal stem cells may re-establish an equilibrium that promotes cell regeneration. This could slow or stop the disease process and restore health to the brain.<\/em><\/p>\n\n\n\n
Prochaines \u00e9tapes de d\u00e9veloppement :<\/strong><\/em>
This trial intends to provide evidence on the safety, effectiveness, and mechanism of action of multiple infusions of mesenchymal stem cells as a treatment to change the progression of Parkinson\u2019s disease. If results are positive, the investigators expect to progress to a large multi-site clinical trial to identify the most effective number of interventions.<\/em><\/p>\n\n\n\n
Researchers<\/strong><\/em><\/p>\n\n\n\n
Mya Caryn Schiess, MD<\/em>
Houston, TX United States<\/em><\/p>\n\n\n\n
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Photo by Michael Longmire<\/a> sur Unsplash<\/a><\/p>\n\n\n\n
<\/p>","protected":false},"excerpt":{"rendered":"
En savoir plus sur le 14e projet soutenu par le DPC<\/p>","protected":false},"author":1,"featured_media":3671,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-1662","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-dpc-supported-research"],"_links":{"self":[{"href":"https:\/\/demoucelle.sites-stag.agency\/fr\/wp-json\/wp\/v2\/posts\/1662","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/demoucelle.sites-stag.agency\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/demoucelle.sites-stag.agency\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/demoucelle.sites-stag.agency\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/demoucelle.sites-stag.agency\/fr\/wp-json\/wp\/v2\/comments?post=1662"}],"version-history":[{"count":4,"href":"https:\/\/demoucelle.sites-stag.agency\/fr\/wp-json\/wp\/v2\/posts\/1662\/revisions"}],"predecessor-version":[{"id":4140,"href":"https:\/\/demoucelle.sites-stag.agency\/fr\/wp-json\/wp\/v2\/posts\/1662\/revisions\/4140"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/demoucelle.sites-stag.agency\/fr\/wp-json\/wp\/v2\/media\/3671"}],"wp:attachment":[{"href":"https:\/\/demoucelle.sites-stag.agency\/fr\/wp-json\/wp\/v2\/media?parent=1662"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/demoucelle.sites-stag.agency\/fr\/wp-json\/wp\/v2\/categories?post=1662"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/demoucelle.sites-stag.agency\/fr\/wp-json\/wp\/v2\/tags?post=1662"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}